Reprogrammed adult cells reverse sickle-cell disease


By Andy Coghlan FOR the dream of personalised medicine using reprogrammed adult cells, it is an important proof of principle. Skin cells taken from mice with a form of sickle-cell anaemia have been reprogrammed back into an embryonic-like state, “corrected” so that they no longer produce defective proteins, and used to reverse the symptoms of the disease. The breakthrough is exciting because it proves that reprogrammed adult cells – believed to be as versatile as stem cells obtained from a human embryo – could be used to cure disease in humans,
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